and products. HRSA will provide funding in the form of a cooperative agreement to support one (1) organization for up to four (4) years to serve as the Innovative Intervention Strategies Coordinating Center for Technical Assistance (2iS CCTA). The 2iS CCTA will solicit and subaward up to 20 Ryan White HIV/AIDS Program (RWHAP)-funded recipients/subrecipients (approximately five sites per focus area) to serve as implementation sites where one intervention strategy per site will be piloted. The piloted intervention strategies will be evaluated through the companion funding opportunity announcement titled Using Innovative Intervention Strategies to Improve Health Outcomes among People with HIV – Evaluation Center (2iS EC; HRSA-21-068). Ultimately, the 2iS EC’s evaluation findings will determine dissemination plans for the replication tools developed by the 2iS CCTA. Please review this companion announcement for more information about the role of the 2iS EC. You may also review the previous initiative for which this is a competing continuation (HRSA-17-044; HRSA-17-049). 2iS Focus Areas This initiative will focus on three (3) priority populations and one (1) area of opportunity to improve service delivery. Combined, these four (4) focus areas are: 1) Improving HIV health outcomes for people with substance use disorder 2) Improving HIV health outcomes for lesbian, gay, bisexual, transgender, or queer (LGBTQ+) youth 3) Improving HIV health outcomes for people who are or have been incarcerated 4) Improving HIV health outcomes by using telehealth services To identify implementation sites to pilot test the intervention strategies identified across the four (4) focus areas, the 2iS CCTA will be responsible for soliciting, selecting, issuing, and monitoring subawards of up to $190,000/year each for up to twenty (20) RWHAP recipients or subrecipients (hereafter referred to as “subawardees”), or up to five (5) per focus area. The 2iS CCTA will select subawardees based on a  demonstrated need and capacity to implement one intervention strategy from one focus area through a competitive application process. The 2iS CCTA will provide TA to the selected subawardees to support successful uptake of the intervention strategy and engagement of clients. The 2iS CCTA will also develop dissemination products that will support the rapid replication of intervention strategies found to be successfully implemented and effective at improving client outcomes in subawardee sites. The companion 2iS EC cooperative agreement (HRSA-21-068) will evaluate the uptake, implementation and associated client outcomes of these intervention strategies at the subawarded sites. Please review the related 2iS EC (HRSA-21-068) announcement to understand the collaborative work between the 2iS CCTA and the 2iS EC.