Broad-Spectrum Antagonists For Editors (B-SAFE)
Agency: DARPA - Biological Technologies Office
Assistance Listings
- 12.910 -- Research and Technology Development
Archived opportunityLast Updated: May 13, 2026
View version history on Grants.gov
Description
The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative proposals to identify and optimize novel molecules that exhibit inhibitory effects on Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated proteins (CRISPR-Cas) gene editing processes. The Broad-Spectrum Antagonists for Editors (B-SAFE) program is explicitly seeking transformative approaches enabling the discovery or design of novel inhibitors of gene editing technologies with enhanced activity, utility, and breadth of coverage. Novel inhibitor activity will be assessed in vitro over the...
course of the program and a subset of top performing molecules will be selected for scale-up at quantities sufficient for testing and evaluation by Department of Defense (DoD) stakeholders. In concert, DARPA is interested in exploring methods to rapidly discover inhibitor molecules for novel gene editing technologies beyond CRISPR-Cas systems to keep pace with the rapidly advancing field and promote the safe, controlled use of these technologies. Research that generates incremental improvements to the existing state-of-the-art are specifically excluded.
Eligibility
Eligible applicants
Miscellaneous
- Other
Additional information
All responsible sources capable of satisfying the Government's needs may submit a proposal that shall be considered by DARPA. See the Eligibility Information section of the BAA for more information.
Grantor contact information
Description
BAA Coordinator
BSAFE@darpa.mil
Documents
Link to additional information
Archived: September 11, 2024
Award
$--
Program Funding
--
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
HR001124S0032
Cost sharing or matching requirement:
No
Funding instrument type:
Other
Cooperative agreement
Procurement contract
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Science technology and other research and development
Category Explanation:
--
History
Version:
2
Posted date:
June 14, 2024
Archive date:
September 11, 2024
