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NIH Director’s Pioneer Award Program (DP1 Clinical Trial Optional)

Agency: National Institutes of Health

Assistance Listings: 93.310 -- Trans-NIH Research Support

Last Updated: December 11, 2025

Description

The NIH Director’s Pioneer Award supports individual scientists of exceptional creativity who propose bold and highly innovative research projects with the potential to produce a major impact on broad, important areas relevant to the mission of NIH. To be considered pioneering, the proposed research must reflect substantially different scientific directions from those already being pursued in the investigator’s research program or elsewhere. Applications in any area within the biomedical sciences are welcome. The NIH Director’s Pioneer Award is a component of the High-Risk, High-Reward Research (HRHR) Program of the NIH Common Fund.

Eligibility

Eligible applicants

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Government

  • Public and Indian housing authorities
  • County governments
  • City or township governments
  • State governments
  • Special district governments
  • Federally recognized Native American tribal governments

Business

  • For-profit organizations other than small businesses
  • Small businesses

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Miscellaneous

  • Other

Additional information

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government, excluding the NIH Intramural Research Program (NIH IRP);U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Grantor contact information

Description

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Email

PioneerAwards@mail.nih.gov

PioneerAwards@mail.nih.gov

Documents

No documents are currently available.

Link to additional information

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Forecasted

Estimated Post Date:

July 9, 2026

Estimated Application Due Date:

September 9, 2026

Estimated Due Date Description:

Not available

Estimated Award Date:

September 15, 2026

Estimated Project Start Date:

September 30, 2026

Fiscal Year:

2027

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$8,100,000

Program Funding

8

Expected awards

$700,000

Award Minimum

$700,000

Award Maximum

Funding opportunity number:

RFA-RM-26-001

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

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Category of Funding Activity:

Health

Category Explanation:

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History

Version:

1

Forecast posted date:

December 11, 2025

Archive date:

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