The NIH Common Fund, National Institute on Aging, National Cancer Institute and additional NIH Institutes and Centers (ICs) intend to publish a Notice of Funding Opportunity (NOFO) to solicit applications for Stage 2 of the Cellular Senescence Network (SenNet) Program, which seeks to understand the biological consequences of senescent cell heterogeneity in health and disease, identify and characterize tissue-specific senescence markers in human biospecimens to facilitate the development of senotherapeutic strategies that improve health outcomes. The program’s SenNet Data Coordination, Integration and Organizational Center (DCIOC) will integrate tissue mapping efforts with Stage 2 data to generate Atlases of Senescence incorporating the spatial distribution of senescence biomarkers with biological and functional data across tissues in health, lifespan and age-associated diseases. The DCIOC will also serve as the organizational hub for SenNet in managing consortium and outreach activities. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U24 or UM1 activity code. Investigators with expertise and insights into the cellular senescence impact on human health, the development of innovative technologies and computational tools to identify and characterize senescent cells and inform novel approaches for the strategic targeting of senescent cells in vivo are encouraged to apply in response to these new NOFOs.

Education

• Independent school districts
• Public and state institutions of higher education
• Private institutions of higher education

Government

• State governments
• Federally recognized Native American tribal governments
• Public and Indian housing authorities
• County governments

Business

• Small businesses
• For-profit organizations other than small businesses

Nonprofit

• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)