The purpose of this Notice of Funding Opportunity (NOFO) is to support SenNet Discovery and Validation Centers (SenNet DVCs) as a core component of Stage 2 of the NIH Common Fund Cellular Senescence Network (SenNet). Building on Stage 1 resources, DVCs will define, refine, and validate tissue- and disease-relevant cellular senescence signatures (“senotypes”) and associated biomarkers, and will investigate their functional consequences in human health and disease. DVCs are expected to generate and contribute high-quality molecular, cellular, and spatial datasets (including relevant metadata and documentation) and to use complementary experimental systems, as appropriate, to validate senotypes/biomarkers and characterize responses to senescence-associated perturbations or senotherapeutic approaches. DVC applications should also propose goals and aims for SenNet consortium-wide organizational and outreach activities (SenNet OOC functions).

Government

• Special district governments
• Federally recognized Native American tribal governments
• Public and Indian housing authorities
• State governments
• City or township governments
• County governments

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Other Native American tribal organizations
• Nonprofits non-higher education without 501(c)(3)

Business

• Small businesses
• For-profit organizations other than small businesses

Miscellaneous

• Other

Education

• Public and state institutions of higher education
• Private institutions of higher education
• Independent school districts