Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)

This Notice of Funding Opportunity (NOFO) invites applications that investigate the etiology of sporadic non-hereditary early-onset cancers (EOCs: ages 18 to 49 years) and the underlying biological mechanisms that play a role in these cancers to inform prevention and control strategies. The proposed research is expected to advance the understanding of the unexplained rise of cancers in young adults. More specifically, studies should focus on one or more of the following: i) identifying what environmental or lifestyle exposures are driving the increase in the incidence of non-hereditary EOCs, and how these factors vary by patient demographics; ii) examining the biological mechanisms and host responses that underlie the increase in EOCs; and iii) identifying how those at increased risk of developing EOCs can be identified more effectively.

In an effort to streamline the application process and sustain momentum in this critical research area, this NOFO  supports both exploratory/developmental and standard research projects through a grant award instrument. 

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Nonprofits non-higher education without 501(c)(3)
• Other Native American tribal organizations

Miscellaneous

• Other

Education

• Independent school districts
• Private institutions of higher education
• Public and state institutions of higher education

Government

• County governments
• State governments
• Federally recognized Native American tribal governments
• Public and Indian housing authorities
• City or township governments
• Special district governments

Business

• For-profit organizations other than small businesses
• Small businesses