The National Institute of Neurological Disorders and Stroke (NINDS), in conjunction with The National Heart, Lung and Blood Institute (NHLBI), at the National Institutes of Health (NIH) seek to continue support for the Infrastructure for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN). The SIREN Network performs clinical trials that impact the care of individuals with a non-stroke neurological and cardiovascular emergency in the pre-hospital or emergency department setting. The goal of SIREN is to improve the outcomes by identifying effective treatments given in the earliest stages of care. The program will encourage applications for a clinical coordinating center (CCC) and data coordinating center (DCC) to support the NIH SIREN clinical trial network. 

Applications are not being solicited at this time. This notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive applications for centers. 

Government

• Federally recognized Native American tribal governments
• State governments
• County governments
• City or township governments
• Special district governments
• Public and Indian housing authorities

Education

• Private institutions of higher education
• Public and state institutions of higher education
• Independent school districts

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Other Native American tribal organizations
• Nonprofits non-higher education without 501(c)(3)

Business

• Small businesses
• For-profit organizations other than small businesses

Miscellaneous

• Other