This NOFO invites applications for investigator-initiated, high-risk multi-center clinical trials involving more than one clinical center. Proposed trials should be hypothesis-driven, have the potential to change clinical practice and/or public health, and focus on a disease relevant to the mission of NIDDK. Planning activities must be completed prior to submission and are not permitted under this NOFO. Applicants who require a planning phase may first apply for an implementation planning cooperative agreement (U34; see TEMP9971).Consultation with NIDDK Scientific/Research staff is strongly encouraged prior to the submission of either a U34 or U01 application.

Government

• Special district governments
• Federally recognized Native American tribal governments
• County governments
• City or township governments
• Public and Indian housing authorities
• State governments

Education

• Private institutions of higher education
• Independent school districts
• Public and state institutions of higher education

Nonprofit

• Nonprofits non-higher education without 501(c)(3)
• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)

Business

• For-profit organizations other than small businesses
• Small businesses

Miscellaneous

• Other