Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)
Agency: National Institutes of Health
Assistance Listings: 93.279 -- Drug Use and Addiction Research Programs
Last Updated: September 10, 2025
Description
The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.
Eligibility
Eligible applicants
Government
- City or township governments
- Public and Indian housing authorities
- State governments
- Federally recognized Native American tribal governments
- County governments
- Special district governments
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Business
- For-profit organizations other than small businesses
- Small businesses
Education
- Public and state institutions of higher education
- Independent school districts
- Private institutions of higher education
Miscellaneous
- Other
Additional information
Other Eligible Applicants include the following:
Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.
Grantor contact information
Description
NIH Grants Information
grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Documents
| File name | Description | Last updated |
|---|---|---|
| PAR-25-446-Full-Announcement.html | PAR-25-446 Full Announcement Text | Sep 10, 2025 05:31 PM UTC |
Link to additional information
https://grants.nih.gov/grants/guide/pa-files/PAR-25-446.html
Closing: August 21, 2028
Award
$--
Program Funding
--
Expected awards
$--
Award Minimum
$3,000,000
Award Maximum
Funding opportunity number:
PAR-25-446
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Education
Health
Category Explanation:
--
History
Version:
1
Posted date:
September 10, 2025
Archive date:
September 26, 2028
