The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on the cerebellum’s contributions to cognitive and affective functions in healthy aging as well as in the context of Alzheimer's disease (AD) and Alzheimer's disease related dementias (ADRD). This NOFO seeks studies to address the need for improved understanding of the physiology and neuroanatomy of the cerebellum in these processes in the context of healthy aging and AD/ADRD. This NOFO welcomes a mix of approaches including basic human and animal model studies, secondary data analyses of existing aging and AD/ADRD datasets, as well as studies examining the cerebellum as a potential target for interventions to promote cognitive reserve and/or prevent and delay the onset of AD/ADRD.