Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)
Agency: National Institutes of Health
Assistance Listings: 93.279 -- Drug Use and Addiction Research Programs
Last Updated: August 27, 2026
Description
The purpose of this notice of funding opportunity (NOFO) is to support innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. This initiative encourages high risk high impact transformative studies that advance knowledge and strategies for HIV prevention, diagnosis, treatment and virus suppression in people who use substances and/or have a substance use disorder.
Eligibility
Eligible applicants
Business
- For-profit organizations other than small businesses
- Small businesses
Nonprofit
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
Education
- Private institutions of higher education
- Public and state institutions of higher education
- Independent school districts
Government
- Federally recognized Native American tribal governments
- County governments
- Special district governments
- State governments
- Public and Indian housing authorities
- City or township governments
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
nidagmbemail@nida.nih.gov
nidagmbemail@nida.nih.gov
nidagmbemail@nida.nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| PAR-27-026-Revised-Full-Announcement.html | PAR-27-026-Revised-Full-Announcement.html | Aug 27, 2026 06:16 PM UTC |
Link to additional information
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Closing: September 25, 2028
Award
$--
Program Funding
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Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
PAR-27-026
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
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Category of Funding Activity:
Health
Category Explanation:
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History
Version:
2
Posted date:
June 9, 2026
Archive date:
November 24, 2028
