Opportunity Listing - Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)

Computational Modeling and Analysis of the Impact of Genomic Variation on Function (UM1, Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.172 -- Human Genome Research

Last Updated: October 9, 2026

Description

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications to develop, apply, and test predictive models and perform integrative analyses to determine the impact of genomic variation on genome function. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers also will collaborate with other consortium components to guide and optimize IGVF experimental design, to provide analytical expertise and support for consortium-wide efforts, and to develop and execute shared analysis strategies to meet consortium goals.

Eligibility

Eligible applicants

Nonprofit

Nonprofits non-higher education with 501(c)(3)
Nonprofits non-higher education without 501(c)(3)
Other Native American tribal organizations

Education

Independent school districts
Public and state institutions of higher education
Private institutions of higher education

Government

Special district governments
City or township governments
Federally recognized Native American tribal governments
Public and Indian housing authorities
State governments
County governments

Business

For-profit organizations other than small businesses
Small businesses

Miscellaneous

Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibilityForeign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Grantor contact information

Description

IGVF Program Team nhgri-igvf@mail.nih.gov

Email

nhgri-igvf@mail.nih.gov

Documents

File name	Description	Last updated
RFA-HG-27-010-Full-Announcement.html	RFA-HG-27-010-Full-Announcement.html	Oct 9, 2026 05:07 PM UTC

Link to additional information

Closing: December 14, 2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$5,000,000

Program Funding

Expected awards

$--

Award Minimum

$800,000

Award Maximum

Funding opportunity number:

RFA-HG-27-010

Cost sharing or matching requirement:

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

October 9, 2026

Archive date:

February 14, 2027