Opportunity Listing - Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)

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Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Basic Experimental Studies with Human Required)

Agency: National Institutes of Health

Assistance Listings: 93.398 -- Cancer Research Manpower

93.273 -- Alcohol Research Programs

93.867 -- Vision Research

93.866 -- Aging Research

93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research

93.121 -- Oral Diseases and Disorders Research

93.865 -- Child Health and Human Development Extramural Research

93.393 -- Cancer Cause and Prevention Research

93.361 -- Nursing Research

93.242 -- Mental Health Research Grants

93.879 -- Medical Library Assistance

93.173 -- Research Related to Deafness and Communication Disorders

93.313 -- NIH Office of Research on Women's Health

93.113 -- Environmental Health

Last Updated: August 25, 2025

View version history on Grants.gov

Description

The Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project that represents a change in research direction for an early stage investigator (ESI) and for which no preliminary data exist. Applications submitted to this Notice of Funding Opportunity Announcement (NOFO) must not include preliminary data. Applications must include a separate attachment describing the change in research direction. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions....

This Funding Opportunity is for basic science experimental studies involving humans, referred to in NOT-OD-18-212 as prospective basic science studies involving human participants. These studies fall within the NIH definition of a clinical trial and also meet the definition of basic research. Types of studies that should submit under this NOFO include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical or behavioral outcomes in humans for the purpose of understanding the fundamental aspects of phenomena without specific application towards processes or products in mind. Studies that are NOT conducted with specific applications toward processes or products in mind and which also do not meet the clinical trial definition should submit under the appropriate Clinical Trial Not Allowed NOFO .

Eligibility

Eligible applicants

Nonprofit

Nonprofits non-higher education without 501(c)(3)
Nonprofits non-higher education with 501(c)(3)
Other Native American tribal organizations

Business

Small businesses
For-profit organizations other than small businesses

Government

County governments
State governments
Federally recognized Native American tribal governments
Special district governments
Public and Indian housing authorities
City or township governments

Miscellaneous

Other

Education

Independent school districts
Public and state institutions of higher education
Private institutions of higher education

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Documents

File name	Description	Last updated
PAR-25-323-Full-Announcement.html	PAR-25-323 Full Announcement Text	Aug 25, 2025 08:46 PM UTC

Link to additional information

https://grants.nih.gov/grants/guide/pa-files/PAR-25-323.html

Closing: August 25, 2028

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

PAR-25-323

Cost sharing or matching requirement:

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Education

Environment

Health

Income security and social services

Category Explanation:

History

Version:

Posted date:

August 25, 2025

Archive date:

September 30, 2028