The purpose of this notice of funding opportunity (NOFO) is to support rigorous analytical validation of method(s) used for measuring biomarkers for neurological and neuromuscular disorders for use in clinical trials or clinical practice. Applicants must justify the unmet need for the biomarker(s) and measurement methods and specify one or two context(s) of use for the biomarker(s). Activities supported include optimizing and evaluating the accuracy, precision, reportable range, and analytical sensitivity and specificity of the detection method across multiple sites and operators and establishing reference intervals and quality control procedures. Multi-site applications are expected but not required.

Education

• Private institutions of higher education
• Independent school districts
• Public and state institutions of higher education

Business

• Small businesses
• For-profit organizations other than small businesses

Nonprofit

• Nonprofits non-higher education without 501(c)(3)
• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)

Government

• County governments
• Federally recognized Native American tribal governments
• State governments
• City or township governments
• Public and Indian housing authorities
• Special district governments

Miscellaneous

• Other