Discovery of in vivo Chemical Probes for the Nervous System (R01 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.866 -- Aging Research
93.279 -- Drug Use and Addiction Research Programs
93.242 -- Mental Health Research Grants
93.867 -- Vision Research
Last Updated: May 13, 2026
Description
The purpose of this Notice of Funding Opportunity (NOFO) is to support investigators who have the interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds (validated hits) for chemical optimization and bioassays for testing new analog compounds.Through this NOFO, NIH wishes to stimulate research in:Discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of National Institute of Mental Health...
(NIMH), National Institute on Drug Abuse (NIDA), National Eye Institute (NEI), and/or National Institute on Aging (NIA) andDiscovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms.Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes.
Eligibility
Eligible applicants
Government
- State governments
- County governments
- Federally recognized Native American tribal governments
- Public and Indian housing authorities
- City or township governments
- Special district governments
Education
- Public and state institutions of higher education
- Private institutions of higher education
- Independent school districts
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
Business
- Small businesses
- For-profit organizations other than small businesses
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
National Institute on Aging (NIA)
NIA-NOFO-Scientific@nih.gov
NIA-NOFO-Scientific@nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| PAR-27-081-Full-Announcement.html | PAR-27-081-Full-Announcement.html | May 4, 2026 03:12 PM UTC |
Link to additional information
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Closing: March 5, 2027
Award
$--
Program Funding
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Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
PAR-27-081
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
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Category of Funding Activity:
Health
Category Explanation:
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History
Version:
1
Posted date:
May 4, 2026
Archive date:
May 4, 2027
