NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)
Agency: National Institutes of Health
Assistance Listings: 93.310 -- Trans-NIH Research Support
Last Updated: June 29, 2026
Description
The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling...
potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.
Eligibility
Eligible applicants
Government
- Special district governments
- City or township governments
- State governments
- Public and Indian housing authorities
- Federally recognized Native American tribal governments
- County governments
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Business
- Small businesses
- For-profit organizations other than small businesses
Education
- Public and state institutions of higher education
- Private institutions of higher education
- Independent school districts
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
NIH Director's Transformative Research Award Program
Transformative_Awards@mail.nih.gov
Transformative_Awards@mail.nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-RM-27-003-Full-Announcement.html | RFA-RM-27-003-Full-Announcement.html | Jun 29, 2026 12:19 PM UTC |
Link to additional information
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Closing: September 3, 2026
Award
$8,000,000
Program Funding
7
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
RFA-RM-27-003
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
June 29, 2026
Archive date:
November 2, 2026
