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NIH SIREN Neurologic Clinical Trials (UG3/UH3 - Clinical Trial Required)
Agency: National Institutes of Health
Assistance Listings: 93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders
Last Updated: August 6, 2025
Description
This announcement (NOFO) encourages applications for multi-center clinical trials focused on neurological emergencies. Successful applicants will collaborate and conduct the trial within the NIH SIREN Network. The NIH SIREN Clinical Coordinating Center (CCC) will work with the successful applicants to implement the proposed trial efficiently and the SIREN Data Coordinating Center (DCC) will provide statistical and data management support. The NIH SIREN hubs and their affiliated clinical sites will provide on-site implementation of the clinical protocols.
The NIH SIREN Network will also be uniquely...
poised to collaborate with other US and international consortia necessary to conduct larger, definitive trials of promising interventions for neurological emergencies.
Multi-center clinical trials in stroke treatment, recovery, or prevention supported by NINDS will be conducted in the NIH StrokeNet, and not within SIREN. Applicants do not need to be part of the existing SIREN infrastructure to apply under this FOA.
Eligibility
Eligible applicants
Government
- Federally recognized Native American tribal governments
- State governments
- City or township governments
- Special district governments
- County governments
- Public and Indian housing authorities
Miscellaneous
- Other
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Business
- Small businesses
- For-profit organizations other than small businesses
Education
- Public and state institutions of higher education
- Independent school districts
- Private institutions of higher education
Additional information
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.
Grantor contact information
Description
NIH Grants Information
grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Documents
No documents are currently available.
Link to additional information
https://grants.nih.gov/grants/guide/pa-files/PAR-25-049.html
Closing: March 6, 2026
Award
$--
Program Funding
--
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
PAR-25-049
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
November 7, 2024
Archive date:
April 11, 2026
