Skip to main content

Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets (U01 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.866 -- Aging Research

Last Updated: March 4, 2026

Description

The National Institute on Aging (NIA) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research on Alzheimer's disease (AD) and AD-related dementias (ADRD) drug target validation and early-stage drug discovery against novel targets. This NOFO will utilize the U01 activity code. The NOFO will support rigorous preclinical AD/ADRD drug target validation and early-stage drug discovery of small molecules, biologic, and emerging therapeutic modalities. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Investigators with expertise and insights into AD/ADRD and drug discovery are encouraged to begin to consider applying for this new NOFO.

Eligibility

Eligible applicants

Miscellaneous

  • Other

Business

  • Small businesses
  • For-profit organizations other than small businesses

Education

  • Public and state institutions of higher education
  • Private institutions of higher education
  • Independent school districts

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Government

  • Special district governments
  • Federally recognized Native American tribal governments
  • County governments
  • City or township governments
  • Public and Indian housing authorities
  • State governments

Additional information

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Grantor contact information

Description

--

Email

NIA-NOFO-Scientific@nih.gov

NIA-NOFO-Scientific@nih.gov

Documents

No documents are currently available.

Link to additional information

--

Forecasted

Estimated Post Date:

July 31, 2026

Estimated Application Due Date:

October 5, 2026

Estimated Due Date Description:

Not available

Estimated Award Date:

July 1, 2027

Estimated Project Start Date:

July 1, 2027

Fiscal Year:

2027

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

--

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

PAR-26-132

Cost sharing or matching requirement:

No

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Forecast posted date:

March 4, 2026

Archive date:

--

HHS.gov

An official website of the U.S. Department of Health and Human Services

Looking for U.S. government information and services? Visit USA.gov