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NIH Director’s Early Independence Awards (DP5 Clinical Trial Optional)

Agency: National Institutes of Health

Assistance Listings: 93.310 -- Trans-NIH Research Support

Last Updated: December 11, 2025

Description

The NIH Director's Early Independence Award supports rigorous and promising investigators who wish to pursue independent research soon after completion of their terminal doctoral degree or post-graduate clinical training, thereby forgoing the traditional post-doctoral training period and accelerating their entry into an independent research career. Applications in any area within the biomedical sciences are welcome. The NIH Director's Early Independence Award is a component of the High-Risk, High-Reward Research program of the NIH Common Fund.

Eligibility

Eligible applicants

Education

  • Private institutions of higher education
  • Independent school districts
  • Public and state institutions of higher education

Miscellaneous

  • Other

Government

  • Federally recognized Native American tribal governments
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Public and Indian housing authorities

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Business

  • Small businesses
  • For-profit organizations other than small businesses

Additional information

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government, including the NIH Intramural Program;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Grantor contact information

Description

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Email

EarlyIndependence@od.nih.gov

EarlyIndependence@od.nih.gov

Documents

No documents are currently available.

Link to additional information

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Forecasted

Estimated Post Date:

July 4, 2026

Estimated Application Due Date:

September 4, 2026

Estimated Due Date Description:

Not available

Estimated Award Date:

September 15, 2026

Estimated Project Start Date:

September 30, 2026

Fiscal Year:

2027

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$5,700,000

Program Funding

10

Expected awards

$350,000

Award Minimum

$350,000

Award Maximum

Funding opportunity number:

RFA-RM-26-004

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

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Category of Funding Activity:

Health

Category Explanation:

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History

Version:

1

Forecast posted date:

December 11, 2025

Archive date:

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