Skip to main content

Impact of Initial Influenza Exposure on Immunity in Infants (U01 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.855 -- Allergy and Infectious Diseases Research

Last Updated: February 10, 2026
The purpose of this notice of funding opportunity (NOFO) is to support the establishment or continuation of longitudinal infant cohorts to determine and compare how initial and repeated natural influenza infections and/or influenza vaccinations shape infant and childhood immunity to future influenza exposures. The goal of this research is to understand how these exposures influence immune responses to subsequent influenza infections and/or vaccines and provide key information to facilitate design of durable, broadly protective influenza vaccines.

Eligibility

Eligible applicants

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations

Government

  • City or township governments
  • County governments
  • Public and Indian housing authorities
  • State governments
  • Special district governments
  • Federally recognized Native American tribal governments

Education

  • Independent school districts
  • Private institutions of higher education
  • Public and state institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Miscellaneous

  • Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Grantor contact information

Description

imprintingNOFO@mail.nih.gov imprintingNOFO@mail.nih.gov

Email

imprintingNOFO@mail.nih.gov

imprintingNOFO@mail.nih.gov

Documents

File nameDescriptionLast updated
RFA-AI-27-019-Full-Announcement.html
RFA-AI-27-019-Full-Announcement.html
Feb 10, 2026 05:03 PM UTC

Link to additional information

--

Closing: June 4, 2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$9,600,000

Program Funding

3

Expected awards

$--

Award Minimum

$3,000,000

Award Maximum

Funding opportunity number:

RFA-AI-27-019

Cost sharing or matching requirement:

No

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Posted date:

February 10, 2026

Archive date:

August 3, 2026

HHS.gov

An official website of the U.S. Department of Health and Human Services

Looking for U.S. government information and services? Visit USA.gov