Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.351 -- Research Infrastructure Programs
Last Updated: December 5, 2025
Description
The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple...
organ systems in order to align with the ORIP"s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs. Applications to develop models that relate strictly to a specific disease or a select area of research or that do not have a broad impact on the NIH-wide research community will not be accepted. Projects that predominantly address the research interests of one NIH IC but are only peripherally related to the research interests of other ICs will also not be accepted, if submitted in response to this notice of funding opportunity (NOFO).
Eligibility
Eligible applicants
Government
- Federally recognized Native American tribal governments
- State governments
- County governments
- City or township governments
Business
- For-profit organizations other than small businesses
- Small businesses
Education
- Public and state institutions of higher education
- Private institutions of higher education
Nonprofit
- Nonprofits non-higher education without 501(c)(3)
- Nonprofits non-higher education with 501(c)(3)
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information of the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Grantor contact information
Description
Office of Research Infrastructure Programs (ORIP)
ORIPDCM@mail.nih.gov
ORIPDCM@mail.nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-OD-25-010-Full-Announcement.html | RFA-OD-25-010-Full-Announcement.html | Dec 5, 2025 06:50 PM UTC |
Link to additional information
--
Closing: September 28, 2028
Award
$5,000,000
Program Funding
6
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
RFA-OD-25-010
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
December 5, 2025
Archive date:
November 2, 2028
