Opportunity Listing - INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome (R21 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.310 -- Trans-NIH Research Support

93.233 -- National Center on Sleep Disorders Research

93.837 -- Cardiovascular Diseases Research

93.121 -- Oral Diseases and Disorders Research

93.395 -- Cancer Treatment Research

93.865 -- Child Health and Human Development Extramural Research

93.867 -- Vision Research

93.855 -- Allergy and Infectious Diseases Research

93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research

93.351 -- Research Infrastructure Programs

93.839 -- Blood Diseases and Resources Research

93.173 -- Research Related to Deafness and Communication Disorders

93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

93.866 -- Aging Research

93.879 -- Medical Library Assistance

93.838 -- Lung Diseases Research

Last Updated: May 13, 2026

View version history on Grants.gov

Description

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. This Notice of Funding Opportunity (NOFO) invites researchers to submit applications for support of new exploratory and developmental research projects that address critical needs for Down syndrome projects, as articulated in the INCLUDE Project objectives. For example, such projects could assess the feasibility of a novel area of investigation or a new experimental system that has the potential to enhance...

health-related research. Another example could include the unique and innovative use of an existing methodology to explore a new scientific area. These studies may involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of biomedical, behavioral, or clinical research.

Eligibility

Eligible applicants

Government

Special district governments
State governments
City or township governments
County governments
Public and Indian housing authorities
Federally recognized Native American tribal governments

Nonprofit

Other Native American tribal organizations
Nonprofits non-higher education without 501(c)(3)
Nonprofits non-higher education with 501(c)(3)

Business

For-profit organizations other than small businesses
Small businesses

Miscellaneous

Other

Education

Independent school districts
Private institutions of higher education
Public and state institutions of higher education

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

The INCLUDE Project DownSyndromeINCLUDE@mail.nih.gov

Email

DownSyndromeINCLUDE@mail.nih.gov

Documents

File name	Description	Last updated
RFA-OD-27-003-Full-Announcement.html	RFA-OD-27-003-Full-Announcement.html	May 12, 2026 03:21 PM UTC

Link to additional information

Closing: June 15, 2028

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$1,000,000

Program Funding

Expected awards

$--

Award Minimum

$200,000

Award Maximum

Funding opportunity number:

RFA-OD-27-003

Cost sharing or matching requirement:

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

May 12, 2026

Archive date:

August 14, 2028