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Maximizing Investigators' Research Award (MIRA) (R35 - Clinical Trial Optional)

Agency: National Institutes of Health

Assistance Listings: 93.859 -- Biomedical Research and Research Training

Last Updated: December 18, 2025
The Maximizing Investigators' Research Award (MIRA) provides support for individual investigators for research within the scientific mission of NIGMS via a single grant to achieve the following:Increase the stability of funding for NIGMS-supported investigators, which could enhance their ability to take on ambitious scientific projects and approach problems more creatively;Increase flexibility for investigators to follow important new research directions within the NIGMS mission as opportunities arise, rather than being bound to specific aims proposed in advance of the studies;More widely distribute...

Eligibility

Eligible applicants

Business

  • For-profit organizations other than small businesses
  • Small businesses

Government

  • State governments
  • Public and Indian housing authorities
  • City or township governments
  • Federally recognized Native American tribal governments
  • County governments
  • Special district governments

Education

  • Private institutions of higher education
  • Public and state institutions of higher education
  • Independent school districts

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Miscellaneous

  • Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Grantor contact information

Description

NIGMS EINI MIRA NIGMS_EINIMIRA@nigms.nih.gov

Email

NIGMS_EINIMIRA@nigms.nih.gov

NIGMS_EINIMIRA@nigms.nih.gov

Documents

File nameDescriptionLast updated
PAR-26-121-Full-Announcement.html
PAR-26-121-Full-Announcement.html
Dec 11, 2025 05:55 PM UTC
PAR-26-121-Revised-Full-Announcement.html
PAR-26-121-Revised-Full-Announcement.html
Dec 18, 2025 07:19 PM UTC

Link to additional information

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Closing: May 26, 2028

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

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Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

PAR-26-121

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

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History

Version:

2

Posted date:

December 11, 2025

Archive date:

July 25, 2028

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