Optimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Clinical Centers (U01 Clinical Trial Required)
Agency: National Institutes of Health
Assistance Listings: 93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research
Last Updated: June 8, 2026
Description
This Notice of Funding Opportunity (NOFO) invites applications from clinical centers to participate in a consortium to test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use. Such intervention strategies should support the promotion of healthy growth and development; adequate nutritional status/intake, healthy eating and physical activity behaviors; mental health and well-being (e.g., body image, self-esteem, mood, etc.), and quality of life and be feasible to implement in clinical care settings. Priority areas include...
testing strategies to determine optimal developmental stage for AOM initiation, rate and amount of weight loss, AOM class, dose, frequency, and duration, and content and intensity of adjunct lifestyle therapies that may be imperative to ensure normal psychological and physical development and to potentially avoid lifelong dependence on AOMs. Investigators should also evaluate potential predictors of response/ nonresponse to various treatment strategies under evaluation. The clinical centers may conduct independent or multicenter trials but will collaborate on the development of protocols, use of common measures and data elements, use of a central laboratory and standardized procedures to collect data and biospecimens, and data analyses and manuscripts. This NOFO uses a cooperative agreement mechanism (U01) and runs in parallel with a companion NOFO (RFA-DK-27-136).
Eligibility
Eligible applicants
Nonprofit
- Nonprofits non-higher education without 501(c)(3)
- Nonprofits non-higher education with 501(c)(3)
- Other Native American tribal organizations
Business
- For-profit organizations other than small businesses
- Small businesses
Education
- Private institutions of higher education
- Independent school districts
- Public and state institutions of higher education
Government
- County governments
- Federally recognized Native American tribal governments
- State governments
- Special district governments
- City or township governments
- Public and Indian housing authorities
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Grantor contact information
Description
Office of Obesity Research
voula.osganian@nih.gov
voula.osganian@nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-DK-27-121-Full-Announcement.html | RFA-DK-27-121-Full-Announcement.html | Jun 8, 2026 06:47 PM UTC |
Link to additional information
--
Closing: October 9, 2026
Award
$3,000,000
Program Funding
3
Expected awards
$--
Award Minimum
$1,000,000
Award Maximum
Funding opportunity number:
RFA-DK-27-121
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
June 8, 2026
Archive date:
December 8, 2026
