Opportunity Listing - Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)

Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research (U01, Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research

93.233 -- National Center on Sleep Disorders Research

93.837 -- Cardiovascular Diseases Research

93.838 -- Lung Diseases Research

93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

93.839 -- Blood Diseases and Resources Research

Last Updated: June 4, 2026

View version history on Grants.gov

Description

The NIH Cardiovascular Repository for Type 1 Diabetes (CaRe-T1D) was created to improve research on type 1 diabetes (T1D) and cardiovascular disease (CVD). Cardiovascular complications remain the top cause of death among people with T1D and greatly shorten lifespan. The mechanisms underlying atherosclerosis, cardiomyopathy, endothelial dysfunction, and cardiac autonomic neuropathy in T1D remain poorly understood. While managing traditional risk factors—such as high blood glucose, high blood pressure, and elevated cholesterol lower cardiovascular risk, a significant residual risk remains even with...

optimal control. In addition to atherosclerosis, both diastolic and systolic diabetic cardiomyopathy play a major role in morbidity and mortality among these patients. Currently, no therapies are specifically approved to prevent or treat these common and severe cardiovascular issues in T1D. The purpose of this NOFO is to promote collaborative and interdisciplinary research aimed at enhancing the understanding of the development of CVD in individuals with T1D and the differences with CVD in T1D by continuing the efforts of the CaRe-T1D consortium.This NOFO is associated with the Special Diabetes Program (https://www.niddk.nih.gov/about-niddk/research-areas/diabetes/type-1-diabetes-special-statutory-funding-program/about-special-diabetes-program) which funds research on the prevention, treatment, and cure of type 1 diabetes and its complications, including unique, innovative, and collaborative research consortia and clinical trials networks.

Eligibility

Eligible applicants

Government

State governments
County governments
Federally recognized Native American tribal governments
Special district governments
City or township governments
Public and Indian housing authorities

Nonprofit

Nonprofits non-higher education with 501(c)(3)
Other Native American tribal organizations
Nonprofits non-higher education without 501(c)(3)

Education

Independent school districts
Public and state institutions of higher education
Private institutions of higher education

Business

For-profit organizations other than small businesses
Small businesses

Miscellaneous

Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

Division of Diabetes, Endocrinology and Metabolic Diseases NIDDK_DEM@nih.gov

Email

NIDDK_DEM@nih.gov

Documents

File name	Description	Last updated
RFA-DK-27-108-Full-Announcement.html	RFA-DK-27-108-Full-Announcement.html	Jun 4, 2026 02:52 PM UTC

Link to additional information

Closing: March 10, 2027

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$6,000,000

Program Funding

Expected awards

$--

Award Minimum

$500,000

Award Maximum

Funding opportunity number:

RFA-DK-27-108

Cost sharing or matching requirement:

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

June 4, 2026

Archive date:

May 9, 2027