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Pilot Projects to Enhance the Human Virome Program (R03 Clinical Trials Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.310 -- Trans-NIH Research Support

Last Updated: October 8, 2026

The Common Fund Human Virome Program (HVP) aims to extensively and comprehensively characterize the "healthy" human virome (the collection of viruses that normally reside inside the human body without evidence of disease) and create tools, models, and methods that will enable an in-depth study of its variation and composition in relation to host factors and its influence on health and disease.

The purpose of this NOFO is to support small pilot projects that extend the goals of the HVP, including further validating, improving, and complementing existing and newly developed tools from the HVP program by leveraging human specimens collected from the cohorts under the program; samples from animals to promote the refinement, utilization, and translation of these tools to better serve the goals of the HVP program; expanding existing cohorts and/or biospecimen sampling sites for virome characterization; developing tools, assays, and methods to study the human virome; and defining functional interactions between the human virome and host. These pilot projects will expand the HVP consortium, and collaboration across the HVP is expected. Applicants outside the current HVP are encouraged to apply and pilot projects should not overlap with existing HVP efforts (visit the Common Fund website for a list of funded research).

Eligibility

Eligible applicants

Government

  • Special district governments
  • State governments
  • County governments
  • City or township governments
  • Public and Indian housing authorities
  • Federally recognized Native American tribal governments

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Education

  • Private institutions of higher education
  • Independent school districts
  • Public and state institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Miscellaneous

  • Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.Regional Organizations;

Grantor contact information

Description

Human Virome Program HumanVirome@od.nih.gov

Email

HumanVirome@od.nih.gov

HumanVirome@od.nih.gov

Documents

File nameDescriptionLast updated
RFA-RM-27-024-Full-Announcement.html
RFA-RM-27-024-Full-Announcement.html
Oct 8, 2026 07:03 PM UTC

Link to additional information

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Closing: November 10, 2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$2,000,000

Program Funding

13

Expected awards

$50,000

Award Minimum

$100,000

Award Maximum

Funding opportunity number:

RFA-RM-27-024

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Posted date:

October 8, 2026

Archive date:

January 9, 2027

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