HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)
Agency: National Institutes of Health
Assistance Listings: 93.837 -- Cardiovascular Diseases Research
Last Updated: May 21, 2026
Description
The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol development, project management, recruitment oversight, performance milestones, and scientific conduct of trials. The CCs will recruit and retain heart failure patients and controls. The CCs will participate in all aspects of conducting a deep phenotyping...
protocol and longitudinal follow-up of HFpEF patients; obtaining tissue biopsies; and recruiting patients for future clinical trials.Eligible applicants may submit proposals for either the CTC or CC, but must have different PIs. Each application should include CTC or CC as part of their project title.Companion NOFO for RFA-HL-27-009 will support a Data Translation Center (DTC) for overall coordination of the HeartShare program.
Eligibility
Eligible applicants
Government
- Federally recognized Native American tribal governments
- Public and Indian housing authorities
- State governments
- City or township governments
- Special district governments
- County governments
Miscellaneous
- Other
Business
- For-profit organizations other than small businesses
- Small businesses
Education
- Public and state institutions of higher education
- Independent school districts
- Private institutions of higher education
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Other Native American tribal organizations
- Nonprofits non-higher education without 501(c)(3)
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
Division of Cardiovascular Sciences, HeartShare Team
nhlbiheartshare@mail.nih.gov
Division of Cardiovascular Sciences, HeartShare Team
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-HL-27-008-Revised-Full-Announcement.html | RFA-HL-27-008-Revised-Full-Announcement.html | May 21, 2026 06:13 PM UTC |
Link to additional information
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Closing: July 9, 2026
Award
$3,465,000
Program Funding
8
Expected awards
$--
Award Minimum
$500,000
Award Maximum
Funding opportunity number:
RFA-HL-27-008
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
3
Posted date:
May 19, 2026
Archive date:
September 7, 2026
