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GREGoRi Innovation Projects (U01 Clinical Trial Optional)

Agency: National Institutes of Health

Assistance Listings: 93.172 -- Human Genome Research

Last Updated: June 18, 2026
The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Eligibility

Eligible applicants

Education

  • Private institutions of higher education
  • Independent school districts
  • Public and state institutions of higher education

Business

  • Small businesses
  • For-profit organizations other than small businesses

Nonprofit

  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Government

  • State governments
  • Public and Indian housing authorities
  • County governments
  • Special district governments
  • City or township governments
  • Federally recognized Native American tribal governments

Miscellaneous

  • Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Grantor contact information

Description

GREGoRi Program Team nhgri-gregor@mail.nih.gov

Email

nhgri-gregor@mail.nih.gov

nhgri-gregor@mail.nih.gov

Documents

File nameDescriptionLast updated
RFA-HG-27-013-Full-Announcement.html
RFA-HG-27-013-Full-Announcement.html
Jun 18, 2026 06:11 PM UTC

Link to additional information

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Closing: October 30, 2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$7,500,000

Program Funding

10

Expected awards

$3

Award Minimum

$500,000

Award Maximum

Funding opportunity number:

RFA-HG-27-013

Cost sharing or matching requirement:

No

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Posted date:

June 18, 2026

Archive date:

December 9, 2026

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