HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)
Agency: National Institutes of Health
Assistance Listings
- 93.121 -- Oral Diseases and Disorders Research
- 93.865 -- Child Health and Human Development Extramural Research
- 93.279 -- Drug Abuse and Addiction Research Programs
- 93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders
- 93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research
- 93.393 -- Cancer Cause and Prevention Research
- 93.213 -- Research and Training in Complementary and Integrative Health
- 93.866 -- Aging Research
- 93.867 -- Vision Research
- 93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research
- 93.273 -- Alcohol Research Programs
Archived opportunityLast Updated: May 13, 2026
View version history on Grants.gov
Description
More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage. In recent decades, there has been an overreliance in the prescription of opioids for chronic pain despite their poor ability to improve function and high addiction liability. This contributed to a significant and alarming epidemic of opioid overdose deaths and addictions. Innovative scientific solutions to develop alternative pain treatment options are thus critically needed.
Through targeted research efforts, the NIH HEAL Initiative aims to support the...
development of safe and effective devices to treat pain with little or no addiction liability. This funding opportunity announcement (FOA) is designed to support interdisciplinary research teams of multiple PD/PIs to investigate the mechanism of action of pain relief by medical devices with the overall goal of optimizing therapeutic outcomes for FDA-approved or -cleared technologies. Program teams are expected to accomplish goals that require considerable synergy and collaborative interactions. Teams must leverage appropriate multi-disciplinary expertise to develop new principles and methods for experimentation, analysis, and interpretation. Teams are encouraged to consider objectives that will produce major advances in the field of pain relief by medical devices.
Eligibility
Eligible applicants
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Government
- City or township governments
- State governments
- County governments
- Federally recognized Native American tribal governments
- Public and Indian housing authorities
- Special district governments
Education
- Public and state institutions of higher education
- Private institutions of higher education
- Independent school districts
Miscellaneous
- Other
Business
- Small businesses
- For-profit organizations other than small businesses
Additional information
Other Eligible Applicants include the following:
Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
NIH Grants Information
grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-NS-23-028-Full-Announcement.html | RFA-NS-23-028 Full Announcement Text | Apr 27, 2023 03:16 PM UTC |
Link to additional information
https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-23-028.html
Archived: July 15, 2025
Award
$--
Program Funding
--
Expected awards
$--
Award Minimum
$1,500,000
Award Maximum
Funding opportunity number:
RFA-NS-23-028
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Income security and social services
Food and nutrition
Health
Education
Category Explanation:
--
History
Version:
1
Posted date:
April 27, 2023
Archive date:
July 15, 2025
