Aging Mammalian Tissues In Vitro (R21 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.866 -- Aging Research
Last Updated: August 26, 2025
Description
This notice of funding opportunity (NOFO) invites applications that propose interdisciplinary research that aims to develop complex mammalian 3-dimensional (3D)in vitromicrophysiological systems (MPS) to model aging and recapitulate aging processes/phenotypes observed in the whole organismin vivo. This NOFO is primarily focused on human cell-derived MPS (e.g., tissue chip, organ-on-chip, tissue organoids). However, systems developed using cells of nonhuman mammalian origin are acceptable for benchmarking, system validation, or when their relevance to understanding human aging biology is justified....
Supported projects will be expected to advance the adoption of MPS in aging biology research and as new human-relevant tools for drug discovery.
This NOFO uses the R21 activity code, which is intended for exploratory research at the early and conceptual stages of project development. Preliminary data are not required. An essential feature of responsive applications is the adoption of a multidisciplinary approach that includes expertise in aging biology and from disciplines such as stem cell biology, tissue and organ physiology, microfluidics, bioengineering, computational biology, pharmacology, and biostatistics.
Eligibility
Eligible applicants
Education
- Private institutions of higher education
- Public and state institutions of higher education
- Independent school districts
Government
- County governments
- Federally recognized Native American tribal governments
- State governments
- Special district governments
- City or township governments
- Public and Indian housing authorities
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Other Native American tribal organizations
- Nonprofits non-higher education without 501(c)(3)
Miscellaneous
- Other
Business
- Small businesses
- For-profit organizations other than small businesses
Additional information
Other Eligible Applicants include the following:
Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Regional Organizations; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.
Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.
Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
NIH Grants Information
grantsinfo@nih.gov
See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-AG-26-014-Full-Announcement.html | RFA-AG-26-014 Full Announcement Text | Aug 26, 2025 04:15 PM UTC |
Link to additional information
https://grants.nih.gov/grants/guide/rfa-files/RFA-AG-26-014.html
Closing: October 20, 2025
Award
$--
Program Funding
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Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
RFA-AG-26-014
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
August 26, 2025
Archive date:
November 25, 2025
