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Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials (R34 Clinical Trial Optional)

Agency: National Institutes of Health

Assistance Listings
  • 93.310 -- Trans-NIH Research Support
  • 93.681 -- Office of Disease Prevention
  • 93.279 -- Drug Use and Addiction Research Programs

Open opportunityLast Updated: Oct 19, 2026

View version history on Grants.gov

The purpose of this notice of funding opportunity (NOFO) is to support pilot and feasibility studies to inform the design and conduct of efficacy, effectiveness, and/or services research trials. Topics may include: 1) developing interventions to prevent substance use, misuse, or progression to substance use disorder; 2) prevention, treatment, or recovery services research, including research addressing comorbid pain and medical and mental health disorders; and 3) HIV eradication research, including implementation science, prevention, treatment and recovery in substance use settings/populations.

Eligibility

Eligible applicants

Business

  • Small businesses
  • For-profit organizations other than small businesses

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Government

  • County governments
  • Special district governments
  • Federally recognized Native American tribal governments
  • State governments
  • City or township governments
  • Public and Indian housing authorities

Miscellaneous

  • Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Grantor contact information

Description

NIDA DESPR Program Staff pilotstudies@mail.nih.gov

Email

pilotstudies@mail.nih.gov

pilotstudies@mail.nih.gov

Documents

File nameDescriptionLast updated
PAR-28-093-Full-Announcement.html
PAR-28-093-Full-Announcement.html
Oct 19, 2026 12:01 PM UTC

Link to additional information

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Closing: July 16, 2029

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

--

Expected awards

$--

Award Minimum

$450,000

Award Maximum

Funding opportunity number:

PAR-28-093

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Posted date:

October 19, 2026

Archive date:

September 16, 2029

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