Pancreatic Cancer Detection Consortium: Research Units (U01 Clinical Trial Optional)
Agency: National Institutes of Health
Assistance Listings: 93.393 -- Cancer Cause and Prevention Research
Last Updated: September 25, 2026
Description
Through this Notice of Funding Opportunity (NOFO), NCI solicits applications for the Research Units (RUs), one of the two scientific components of the Pancreatic Cancer Detection Consortium (PCDC), to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify patients who are at high risk of progression to cancer. The PCDC will continue to address one of the four research priorities identified in the NCI's 2014 Scientific Framework for Pancreatic Ductal Adenocarcinoma (PDAC). The PCDC will support research for the development...
and testing of new molecular and imaging biomarkers for detecting PDAC early and for identifying patients at high risk of PDAC (because of genetic factors, family history and/or the presence of precursor lesions) who could be candidates for early intervention. The PCDC-RUs will consist of multi-disciplinary teams and will undertake studies to: identify and test biomarkers measurable in bodily fluids for early detection of PDAC and/or its precursor lesions; develop molecular- and/or imaging-based markers of pancreatic cysts and determine which lesions are likely to progress to cancer; develop molecular- and/or imaging-based approaches for screening populations at high risk of PDAC; use machine learning and computational approaches towards biomarker discovery and/or validation; and conduct biomarker validation studies. The PCDC-RUs will also collect longitudinal biospecimens for building a biorepository. Each PCDC-RU is expected to participate in collaborative activities with other PCDC-RUs and share ideas, biospecimens, and data within the Consortium.
Eligibility
Eligible applicants
Government
- Public and Indian housing authorities
- State governments
- Federally recognized Native American tribal governments
- City or township governments
- Special district governments
- County governments
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education without 501(c)(3)
- Nonprofits non-higher education with 501(c)(3)
Business
- For-profit organizations other than small businesses
- Small businesses
Education
- Private institutions of higher education
- Public and state institutions of higher education
- Independent school districts
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Grantor contact information
Description
Cancer Biomarker Branch National Cancer Institute (NCI)
ncipcdc@nih.gov
ncipcdc@nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| PAR-28-056-Full-Announcement.html | PAR-28-056-Full-Announcement.html | Sep 25, 2026 06:44 PM UTC |
Link to additional information
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Closing: November 5, 2029
Award
$--
Program Funding
--
Expected awards
$--
Award Minimum
$600,000
Award Maximum
Funding opportunity number:
PAR-28-056
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
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Category of Funding Activity:
Health
Category Explanation:
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History
Version:
1
Posted date:
September 25, 2026
Archive date:
January 4, 2030
