Metastasis Research Network (U54 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.396 -- Cancer Biology Research
Last Updated: June 4, 2026
Description
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Towards this goal, the NCI will support U54 Specialized Centers that together will continue to serve as the hub of the Metastasis Research Network (MetNet). Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. The projects should use integrative system level approaches to elucidate...
and integrate a mechanistic understanding of the non-linear, dynamic, and emergent processes in metastasis. Overarching themes should encompass the interplay between at least two central elements in the metastatic process such as early dissemination, cellular, soluble and/or physical microenvironment crosstalk, dormancy, or mechanisms of responses by metastatic cells to therapies. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers.Research proposed by MetNet Centers is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.
Eligibility
Eligible applicants
Government
- City or township governments
- Public and Indian housing authorities
- Federally recognized Native American tribal governments
- Special district governments
- State governments
- County governments
Business
- For-profit organizations other than small businesses
- Small businesses
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Education
- Public and state institutions of higher education
- Independent school districts
- Private institutions of higher education
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
NCI MetNet Research Program
NCIMetNet@mail.nih.gov
NCIMetNet@mail.nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-CA-27-012-Full-Announcement.html | RFA-CA-27-012-Full-Announcement.html | Jun 4, 2026 02:43 PM UTC |
Link to additional information
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Closing: September 25, 2026
Award
$6,800,000
Program Funding
4
Expected awards
$--
Award Minimum
$1,300,000
Award Maximum
Funding opportunity number:
RFA-CA-27-012
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
June 4, 2026
Archive date:
November 24, 2026
