Glioblastoma Therapeutics Network (GTN) (U19 Clinical Trial Required)
Agency: National Institutes of Health
Assistance Listings: 93.394 -- Cancer Detection and Diagnosis Research
93.395 -- Cancer Treatment Research
Last Updated: August 31, 2026
Description
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on novel therapies for adult glioblastoma (GBM). The goal is to improve the treatment of adult GBM by developing novel effective agents that can cross the blood brain barrier (BBB) and testing them clinically. Successful early-stage trials of new drugs from this NOFO would transition seamlessly to later stage trials using well-established NCI clinical trial mechanisms.To implement this concept, a highly collaborative GBM Therapeutics Network (GTN) of cross-cutting teams will...
be established, each team capable of driving therapeutic agent(s) from pre-clinical development, through investigational new drugs (IND) studies, into pilot clinical studies in humans. Appropriate therapeutic agents include: (1) novel agents or (2) agents or combinations approved for other indications and repurposed for treatment of GBM following appropriate preclinical studies. The scope of the NOFO, from late pre-clinical through early (Phase 0/1) clinical studies, uniquely spans a gap in the GBM drug development process.
Eligibility
Eligible applicants
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
Government
- Public and Indian housing authorities
- State governments
- City or township governments
- Special district governments
- Federally recognized Native American tribal governments
- County governments
Education
- Private institutions of higher education
- Public and state institutions of higher education
- Independent school districts
Business
- For-profit organizations other than small businesses
- Small businesses
Miscellaneous
- Other
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Grantor contact information
Description
NCI GTN Program National Cancer Institute (NCI)
GTN-contacts@nih.gov
National Cancer Institute (NCI)
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-CA-27-005-Full-Announcement.html | RFA-CA-27-005-Full-Announcement.html | Aug 31, 2026 01:35 PM UTC |
Link to additional information
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Closing: October 1, 2026
Award
$4,400,000
Program Funding
4
Expected awards
$--
Award Minimum
$700,000
Award Maximum
Funding opportunity number:
RFA-CA-27-005
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
August 31, 2026
Archive date:
November 30, 2026
