Advanced Development and Validation of Emerging Technologies for Basic and Clinical Cancer Research (R33 Clinical Trial Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.394 -- Cancer Detection and Diagnosis Research
Last Updated: June 3, 2026
Description
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites grant applications proposing exploratory research projects focused on further development and technical validation of emerging technologies offering novel capabilities for the molecular or cellular characterization of cancer or for improved handling and quality control of biospecimens used for basic, clinical, or epidemiological cancer research. This NOFO solicits R33 applications where major feasibility gaps for the technology or methodology have been overcome, as demonstrated with supportive preliminary...
data, but still require further development and rigorous technical validation to encourage adoption by the research community. Well-suited applications must propose the development of technologies that offer the potential to accelerate and/or enhance research in the areas of cancer biology, early detection and screening, clinical diagnosis, treatment, cancer control, epidemiology. Technologies proposed for development may have potential for widespread applicability but must be focused in this proposal on cancer-relevant use cases. Projects proposing to apply or use existing technologies for hypothesis-driven research where the novelty resides in the biological or clinical target/question being pursued are not responsive to this solicitation and will not be reviewed.This funding opportunity is part of a broader NCI-sponsored Innovative Molecular Analysis Technologies (IMAT) Program.
Eligibility
Eligible applicants
Business
- For-profit organizations other than small businesses
- Small businesses
Government
- Federally recognized Native American tribal governments
- State governments
- County governments
- Special district governments
- City or township governments
- Public and Indian housing authorities
Miscellaneous
- Other
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Education
- Independent school districts
- Public and state institutions of higher education
- Private institutions of higher education
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Grantor contact information
Description
National Cancer Institute (NCI)
NCI-IMAT@nih.gov
NCI-IMAT@nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-CA-27-002-Full-Announcement.html | RFA-CA-27-002-Full-Announcement.html | Jun 3, 2026 07:28 PM UTC |
Link to additional information
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Closing: November 10, 2026
Award
$5,900,000
Program Funding
13
Expected awards
$--
Award Minimum
$300,000
Award Maximum
Funding opportunity number:
RFA-CA-27-002
Cost sharing or matching requirement:
No
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
June 3, 2026
Archive date:
January 9, 2027
