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Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.121 -- Oral Diseases and Disorders Research

Last Updated: June 4, 2026
This Notice of Funding Opportunity (NOFO) invites applications for innovative research on the factors that cause human behaviors and the oral-systemic health impacts of those behaviors to enhance health, lengthen life, and reduce illness and disability among people with chronic conditions. Causal hypotheses may include biological, biopsychosocial, congenital, environmental, interpersonal, neurological, psychological, and comorbidity factors that individually, sequentially, or in combination trigger human behaviors and oral-systemic health outcomes, with impacts that may be direct or traceably distal. Applications that propose projects to develop or refine causal hypotheses also are encouraged.

Eligibility

Eligible applicants

Government

  • State governments
  • City or township governments
  • Federally recognized Native American tribal governments
  • Public and Indian housing authorities
  • Special district governments
  • County governments

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education without 501(c)(3)
  • Nonprofits non-higher education with 501(c)(3)

Education

  • Public and state institutions of higher education
  • Independent school districts
  • Private institutions of higher education

Business

  • For-profit organizations other than small businesses
  • Small businesses

Miscellaneous

  • Other

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grantor contact information

Description

National Institute of Dental and Craniofacial Research (NIDCR) deeranotifications@nidcr.nih.gov

Email

deeranotifications@nidcr.nih.gov

deeranotifications@nidcr.nih.gov

Documents

File nameDescriptionLast updated
PAR-27-057-Full-Announcement.html
PAR-27-057-Full-Announcement.html
Jun 4, 2026 04:46 PM UTC

Link to additional information

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Closing: July 5, 2029

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

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Expected awards

$--

Award Minimum

$500,000

Award Maximum

Funding opportunity number:

PAR-27-057

Cost sharing or matching requirement:

No

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Posted date:

June 4, 2026

Archive date:

September 3, 2029

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