Opportunity Listing - NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)

NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)

Agency: National Institutes of Health

Assistance Listings: 93.837 -- Cardiovascular Diseases Research

93.395 -- Cancer Treatment Research

93.307 -- Minority Health and Health Disparities Research

93.866 -- Aging Research

93.273 -- Alcohol Research Programs

93.865 -- Child Health and Human Development Extramural Research

93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

93.394 -- Cancer Detection and Diagnosis Research

93.839 -- Blood Diseases and Resources Research

93.233 -- National Center on Sleep Disorders Research

93.393 -- Cancer Cause and Prevention Research

93.351 -- Research Infrastructure Programs

93.350 -- National Center for Advancing Translational Sciences

93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research

93.242 -- Mental Health Research Grants

93.867 -- Vision Research

93.838 -- Lung Diseases Research

93.313 -- NIH Office of Research on Women's Health

93.855 -- Allergy and Infectious Diseases Research

93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders

93.859 -- Biomedical Research and Research Training

Last Updated: May 28, 2026

View version history on Grants.gov

Description

The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).

Eligibility

Eligible applicants

Business

Small businesses

Additional information

Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project. This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first six due dates following the expiration of their budget period. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.

Grantor contact information

Description

NIH SEED (Small business Education and Entrepreneurial Development) SEEDinfo@nih.gov

Email

NIH SEED (Small business Education and Entrepreneurial Development)

SEEDinfo@nih.gov

Documents

File name	Description	Last updated
PA-27-101-Full-Announcement.html	PA-27-101-Full-Announcement.html	May 28, 2026 07:02 PM UTC

Link to additional information

Closing: April 5, 2029

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

PA-27-101

Cost sharing or matching requirement:

Yes

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

May 28, 2026

Archive date:

June 4, 2029