NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
Agency: National Institutes of Health
Assistance Listings
- 93.837 -- Cardiovascular Diseases Research
- 93.395 -- Cancer Treatment Research
- 93.307 -- Minority Health and Health Disparities Research
- 93.866 -- Aging Research
- 93.273 -- Alcohol Research Programs
- 93.865 -- Child Health and Human Development Extramural Research
- 93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
- 93.394 -- Cancer Detection and Diagnosis Research
- 93.839 -- Blood Diseases and Resources Research
- 93.233 -- National Center on Sleep Disorders Research
- 93.393 -- Cancer Cause and Prevention Research
- 93.351 -- Research Infrastructure Programs
- 93.350 -- National Center for Advancing Translational Sciences
- 93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research
- 93.242 -- Mental Health Research Grants
- 93.867 -- Vision Research
- 93.838 -- Lung Diseases Research
- 93.313 -- NIH Office of Research on Women's Health
- 93.855 -- Allergy and Infectious Diseases Research
- 93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders
- 93.859 -- Biomedical Research and Research Training
Open opportunityLast Updated: Jun 1, 2026
View version history on Grants.gov
Description
The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).
Eligibility
Eligible applicants
Business
- Small businesses
Additional information
Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project. This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first six due dates following the expiration of their budget period. Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Unfunded international collaborations or unfunded foreign components, as defined in the NIH Grants Policy Statement, may be allowed.
Grantor contact information
Description
NIH SEED (Small business Education and Entrepreneurial Development)
SEEDinfo@nih.gov
NIH SEED (Small business Education and Entrepreneurial Development)
Documents
| File name | Description | Last updated |
|---|---|---|
| PA-27-101-Revised-Full-Announcement.html | PA-27-101-Revised-Full-Announcement.html | Jun 1, 2026 04:56 PM UTC |
Link to additional information
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Closing: April 5, 2029
Award
$--
Program Funding
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Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
PA-27-101
Cost sharing or matching requirement:
Yes
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
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Category of Funding Activity:
Health
Category Explanation:
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History
Version:
2
Posted date:
May 28, 2026
Archive date:
June 4, 2029
