Mechanistic Exploration of Therapeutic Targets and Treatable Traits to Improve CNS Outcomes in People with HIV
Agency: National Institutes of Health
Assistance Listings: 93.242 -- Mental Health Research Grants
Last Updated: June 9, 2025
Description
The National Institute of Mental Health intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research to identify modifiable targets and mechanisms to alleviate clinically relevant central nervous system (CNS) complications in people with HIV. This NOFO supports research that leverages patient derived data and innovative model platforms to identify and validate novel therapeutic targets underlying CNS complications. Building on advances in systems biology, this initiative seeks to identify modifiable mechanisms contributing to CNS dysfunction through clinical studies or pre-clinical model systems. The ultimate goal is to accelerate the development of effective, mechanism-based interventions that address the multifactorial and heterogeneous nature of CNS complications. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise in systems biology, pre-clinical models, clinical trial methodologies and translational neurobiology should consider applying to this NOFO.
Eligibility
Eligible applicants
Education
- Independent school districts
- Public and state institutions of higher education
- Private institutions of higher education
Government
- County governments
- State governments
- Public and Indian housing authorities
- Federally recognized Native American tribal governments
Business
- For-profit organizations other than small businesses
- Small businesses
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
Additional information
Grantor contact information
Description
vasudev.rao@nih.gov
Documents
No documents are currently available here
Link to additional information
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Forecasted
Estimated Post Date:
September 11, 2025
Estimated Application Due Date:
November 11, 2025
Estimated Due Date Description:
Not available
Estimated Award Date:
July 1, 2026
Estimated Project Start Date:
July 1, 2026
Fiscal Year:
2026
Award
$3,000,000
Program Funding
6
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
FOR-MH-26-165
Cost sharing or matching requirement:
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
Category of Funding Activity:
Health
Category Explanation:
History
Version:
1
Forecast posted date:
June 9, 2025
Archive date:
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