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Mechanistic Exploration of Therapeutic Targets and Treatable Traits to Improve CNS Outcomes in People with HIV

Agency: National Institutes of Health

Assistance Listings: 93.242 -- Mental Health Research Grants

Last Updated: June 9, 2025

Description

The National Institute of Mental Health intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research to identify modifiable targets and mechanisms to alleviate clinically relevant central nervous system (CNS) complications in people with HIV. This NOFO supports research that leverages patient derived data and innovative model platforms to identify and validate novel therapeutic targets underlying CNS complications. Building on advances in systems biology, this initiative seeks to identify modifiable mechanisms contributing to CNS dysfunction through clinical studies or pre-clinical model systems. The ultimate goal is to accelerate the development of effective, mechanism-based interventions that address the multifactorial and heterogeneous nature of CNS complications. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the R01 activity code. Investigators with expertise in systems biology, pre-clinical models, clinical trial methodologies and translational neurobiology should consider applying to this NOFO. 

Eligibility

Eligible applicants

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Government

  • County governments
  • State governments
  • Public and Indian housing authorities
  • Federally recognized Native American tribal governments

Business

  • For-profit organizations other than small businesses
  • Small businesses

Nonprofit

  • Other Native American tribal organizations
  • Nonprofits non-higher education with 501(c)(3)

Additional information

Grantor contact information

Description

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Email

vasudev.rao@nih.gov

vasudev.rao@nih.gov

Documents

No documents are currently available here

Link to additional information

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Forecasted

Estimated Post Date:

September 11, 2025

Estimated Application Due Date:

November 11, 2025

Estimated Due Date Description:

Not available

Estimated Award Date:

July 1, 2026

Estimated Project Start Date:

July 1, 2026

Fiscal Year:

2026

Application process

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Award

$3,000,000

Program Funding

6

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

FOR-MH-26-165

Cost sharing or matching requirement:

No

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

--

Category of Funding Activity:

Health

Category Explanation:

--

History

Version:

1

Forecast posted date:

June 9, 2025

Archive date:

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