Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.351 -- Research Infrastructure Programs
Last Updated: June 9, 2025
Description
The Division of Program Coordination, Planning and Strategic Initiatives, Office of Research Infrastructure Programs (ORIP) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs); or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP’s NIH-wide mission and programs. Applications must describe the need for and the potential impact of the proposed resources on the research community across a range of scientific disciplines supported by multiple NIH ICs.
...This NOFO will utilize the R24 activity code to support research projects that will enhance the capability of resources to serve biomedical research. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. Details of the planned NOFO are provided below.
Research Initiative Details
ORIP’s intent with this NOFO is to support resource-related research projects aimed at developing and characterizing new model resources, improving existing resources, developing NAMs, or acquiring deep understanding of a model system to improve the utilization, accessibility, and translational value of experimental research models to the research community. An application may be predominantly research based if that research potentially leads to the development of tools or resources that will have a broad impact on the biomedical research community. An application also may be aimed at final development or enhancement of existing resources. Applications should:
- Demonstrate the need for the proposed resources or technologies/tools.
- Address the impact, benefit, utilization, distribution, and accessibility of the proposed resources and technologies/tools.
- Describe plans to track potential impact of the proposed resources and technologies/tools.
- Describe plans to ensure the continued availability of the resources and technologies/tools to the research community.
- Include replication and validation plan for proposed models or related resources to be developed.
Examples of resource-related projects suitable for this funding opportunity include, but are not limited to, development of mutant or transgenic models, NAMs, antibodies or other reagents, information resources, and informatics tools, and methods or tools for improving cryopreservation of genetic stocks, advancing techniques of regenerative medicine in models, and enhancing rigor and reproducibility of animal research.
Eligibility
Eligible applicants
Business
- For-profit organizations other than small businesses
- Small businesses
Government
- County governments
- Federally recognized Native American tribal governments
- State governments
Education
- Public and state institutions of higher education
- Private institutions of higher education
Nonprofit
- Other Native American tribal organizations
- Nonprofits non-higher education with 501(c)(3)
Additional information
Grantor contact information
Description
sige.zou@nih.gov
Documents
No documents are currently available here
Link to additional information
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Forecasted
Estimated Post Date:
September 26, 2025
Estimated Application Due Date:
January 25, 2026
Estimated Due Date Description:
Not available
Estimated Award Date:
October 1, 2026
Estimated Project Start Date:
December 1, 2026
Fiscal Year:
2027
Award
$5,000,000
Program Funding
6
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
TEMP-30619
Cost sharing or matching requirement:
Funding instrument type:
Grant
Opportunity Category:
Discretionary
Opportunity Category Explanation:
Category of Funding Activity:
Health
Category Explanation:
History
Version:
1
Forecast posted date:
June 9, 2025
Archive date:
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