Biological and Environmental Interactions of Nanoscale Materials

and other nanoparticles.Such nanomaterials and systems frequently exhibit novel physical, chemical, and biological behavior in living systems andenvironmental matrices as compared to the bulk scale. This program supports research that explores the interaction of nanomaterials in biological and environmental media. Research areas supported by the program include:

• Characterization of interactions at the interfacesbetween nanomaterials and nanosystems with surrounding biological and environmental media, including both simple nanoparticles andcomplex and/or heterogeneous composites;
• Development of predictive toolsbased on the fundamental behavior of nanostructures within biological and ecological matrices to advancecost-effective and environmentally benign processing and engineeringsolutions over full life material cycles;
• Examining the transport, interaction, and impact of nanostructured materials and nanosystems on biological systems;
• Simulations of nanoparticle behavior at interfaces, in conjunction with experimental comparisons, and new theories and simulation approaches for determining the transport and transformation of nanoparticles in various media.

Research in these areas will enable the design of nanostructured materials and heterogeneous nanosystems with optimal chemical, electronic, photonic, biological, and mechanical properties for their safe handling, management, and utilization. Innovative proposals outside of these specific interest areas may be considered. However, prior to submission, it is recommended that the PI contact the Program Director to avoid the possibility of the proposal being returned without review. The duration of unsolicited awards is generally one to three years.The typical award size for the program is $100,000 per year.Proposals requesting a substantially higher amountthan this, without prior consultation with the Program Director, may be returned without review. INFORMATION COMMON TO MOST CBET PROGRAMS Proposals should address the novelty and/orpotentially transformative natureof the proposed work compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and/or industry of success in the research.The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. Faculty Early Career Development(CAREER)program proposals are strongly encouraged.Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Please see the CAREER URLherefor more information. Proposals for Conferences, Workshops, and Supplements: PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal. Grants forRapid Response Research(RAPID)andEArly-concept Grants for Exploratory Research(EAGER)are also considered when appropriate.Please note that proposals of these types must be discussed with the program director before submission. Further details are available in theProposal and Award Policies and Procedures Guide(PAPPG)download foundhere.Grant Opportunities for Academic Liaison with Industry (GOALI)proposals that integrate fundamental research with translational results and are consistent with the application areas of interest to each program are also encouraged. Please note that GOALI proposals must be submitted during the annual unsolicited proposal window for each program. More information on GOALI can be foundhere. COMPLIANCE: Proposals which are not compliant with theProposal and Award Policies and Procedures Guide (PAPPG)will be returned without review. Unsolicited proposals received outside of the Announced Proposal Window dates will be returned without review.