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PRIMED-AI: Validation Center (U54 Clinical Trial Not Allowed) 

Agency: National Institutes of Health

Assistance Listings: 93.310 -- Trans-NIH Research Support

Last Updated: June 6, 2025

Description

The NIH Common Fund, with other NIH Institutes and Centers (ICs), intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Precision Medicine with Artificial Intelligence - Integrating Imaging with Multimodal Data (PRIMED-AI) program, which seeks to develop innovative, reliable, and cost-effective AI-based tools that integrate clinical imaging with other health data types to enhance personalized medicine for patients with chronic and other health conditions. The program’s Validation Center initiative will serve as an independent hub for third party verification, validation, and uncertainty quantification of AI-enabled, image-based, multimodal Clinical Decision Support (CDS) tools through the systematic retesting and harmonization of PRIMED-AI deliverables to comprehensively characterize performance of the CDS tools. Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U54 activity code. Investigators with expertise and insights into the validation of CDS tools and the confidence bounds and potential failure modes of AI predictions are encouraged to begin to consider applying for this new NOFO. 

Eligibility

Eligible applicants

Government

  • Public and Indian housing authorities
  • County governments
  • Federally recognized Native American tribal governments

Nonprofit

  • Nonprofits non-higher education with 501(c)(3)
  • Other Native American tribal organizations

Business

  • Small businesses
  • For-profit organizations other than small businesses

Education

  • Independent school districts
  • Public and state institutions of higher education
  • Private institutions of higher education

Additional information

Grantor contact information

Description

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Email

ODPRIMED-AI@od.nih.gov

ODPRIMED-AI@od.nih.gov

Documents

No documents are currently available here

Link to additional information

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Forecasted

Estimated Post Date:

July 1, 2025

Estimated Application Due Date:

November 1, 2025

Estimated Due Date Description:

Not available

Estimated Award Date:

September 1, 2026

Estimated Project Start Date:

September 1, 2026

Fiscal Year:

2026

Application process

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Award

$3,900,000

Program Funding

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Expected awards

$--

Award Floor

$--

Award Ceiling

Funding opportunity number:

NOT-RM-25-025

Cost sharing or matching requirement:

No

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

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Category of Funding Activity:

Health

Category Explanation:

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History

Version:

1

Posted date:

June 6, 2025

Archive date:

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