Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)
Agency: National Institutes of Health
Assistance Listings: 93.310 -- Trans-NIH Research Support
Last Updated: June 30, 2026
Description
The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools...
into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal CDS tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable. The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Clinic NOFOs.
Eligibility
Eligible applicants
Government
- Special district governments
- Public and Indian housing authorities
- Federally recognized Native American tribal governments
- State governments
- County governments
- City or township governments
Miscellaneous
- Other
Business
- Small businesses
- For-profit organizations other than small businesses
Education
- Independent school districts
- Public and state institutions of higher education
- Private institutions of higher education
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Nonprofits non-higher education without 501(c)(3)
- Other Native American tribal organizations
Additional information
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Grantor contact information
Description
PRIMED-AI Program
ODPRIMED-AI@od.nih.gov
ODPRIMED-AI@od.nih.gov
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-RM-27-014-Full-Announcement.html | RFA-RM-27-014-Full-Announcement.html | Jun 30, 2026 03:02 PM UTC |
Link to additional information
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Closing: October 2, 2026
Award
$2,700,000
Program Funding
1
Expected awards
$--
Award Minimum
$2,000,000
Award Maximum
Funding opportunity number:
RFA-RM-27-014
Cost sharing or matching requirement:
No
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
--
Category of Funding Activity:
Health
Category Explanation:
--
History
Version:
1
Posted date:
June 30, 2026
Archive date:
December 1, 2026
