This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial results through accrual in a variety of community settings. The purpose of NCORP is to engage cancer patient populations, those at risk of cancer, and organizations in rigorous studies focused on cancer control, prevention, treatment and care delivery.

NCORP will support the following components that will be individually awarded through the respective Request for Applications (RFAs) indicated below:

• NCORP Research Bases (UG1 Clinical Trials Required);
• NCORP Community Sites (UG1 Clinical Trials Not Allowed); and
• NCORP Academic Community Sites (UG1 Clinical Trials Not Allowed) 

NCORP Research Bases will serve as research hubs for the NCORP network. Research Bases are expected to:

• Provide an established organizational structure, with scientific and statistical leadership for developing, implementing, and analyzing multi-institutional cancer control, prevention, and care delivery (CCP&CD) clinical research, as well as quality-of-life studies embedded within treatment and imaging studies.
• Assume responsibility for study operations and data management, including efficient protocol development, compliance with Food and Drug Administration (FDA) and Office of Human Research Protections (OHRP) regulatory and participant protection requirements, audits, training, quality assurance, and support to Community Sites and Minority/Underserved Community Sites.
• Conduct their research activities at an institution with comprehensive expertise in cancer clinical research, such as a cancer foundation, healthcare research organization (including NCI's National Clinical Trials Network Group Operations Centers), or NCI-designated Cancer Center.
• Integrate health disparities across all focus areas as appropriate.

The scope of research activities for the proposed NCORP Research Bases encompasses three major areas delineated below:

Area 1: Cancer Control Research; and/or

Area 2: Cancer Prevention Research; and

Area 3: Cancer Care Delivery Research.

Research Bases must cover Area 1. Areas 2 and 3 are optional. 

Business

• For-profit organizations other than small businesses
• Small businesses

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Other Native American tribal organizations

Education

• Public and state institutions of higher education
• Private institutions of higher education

Government

• State governments
• County governments
• Federally recognized Native American tribal governments