The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for the Impact of Genomic Variation on Function (IGVF) Data and Coordinating Center (DACC). The DACC will serve as the coordinating center for the IGVF Consortium and will be responsible for expanding and further developing a broadly accessible set of resources, including a data portal and a comprehensive and searchable catalog of measured and predicted variant impacts. The DACC will also seek input on the design of the catalog from the broader research community, organize and facilitate consortium activities, and seek opportunities to work with other programs and consortia. As a member of IGVF, the DACC will work with all consortium members to maximize the consortium’s overall scientific impact and contribute to accelerating understanding of genomic variation.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2025. This NOFO will utilize the U24 activity code. Details of the planned NOFO are provided below.

Education

• Private institutions of higher education
• Independent school districts
• Public and state institutions of higher education

Government

• State governments
• County governments
• Federally recognized Native American tribal governments
• Public and Indian housing authorities

Business

• Small businesses
• For-profit organizations other than small businesses

Nonprofit

• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)