The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications for research to characterize genomic variation to assess the impact of individual variants on genome function. This will be accomplished by systematically perturbing variants or elements using one or more high-throughput methods; collecting data on the effects of variants in DNA, RNA, or protein-coding elements on molecular, cellular, or organismal phenotypes; and developing robust, reproducible, and portable data processing pipelines. Centers funded through this initiative will become a part of the Impact of Genomic Variation on Function (IGVF) Consortium. As consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. 

The NOFO is expected to be published in 2025 with an expected application due date in 2025.

This NOFO will utilize the UM1 activity code. Details of the planned NOFO are provided below.

Government

• State governments
• Federally recognized Native American tribal governments
• County governments
• Public and Indian housing authorities

Education

• Private institutions of higher education
• Independent school districts
• Public and state institutions of higher education

Nonprofit

• Nonprofits non-higher education with 501(c)(3)
• Other Native American tribal organizations

Business

• Small businesses