Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)

Agency: National Institutes of Health

93.350 -- National Center for Advancing Translational Sciences
93.866 -- Aging Research
93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 -- Child Health and Human Development Extramural Research
93.837 -- Cardiovascular Diseases Research
93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research
93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research
93.855 -- Allergy and Infectious Diseases Research
93.172 -- Human Genome Research
93.838 -- Lung Diseases Research
93.121 -- Oral Diseases and Disorders Research
93.839 -- Blood Diseases and Resources Research
93.233 -- National Center on Sleep Disorders Research

Archived opportunityLast Updated: May 13, 2026

Description

The objective of this Notice of Funding Opportunity (NOFO) is to invite new and renewal applications for the Rare Diseases Clinical Research Consortia (RDCRC) that comprise the Rare Diseases Clinical Research Network (RDCRN). The RDCRCs are intended to advance and improve diagnosis, management, and treatment of numerous, rare diseases through highly collaborative, multi-site, patient-centric, translational, and clinical research. Special emphasis will be placed on the early and timely identification of individuals with rare diseases and clinical trial readiness.

Eligibility

Eligible applicants

Education

Independent school districts
Public and state institutions of higher education
Private institutions of higher education

Nonprofit

Nonprofits non-higher education with 501(c)(3)
Other Native American tribal organizations

Government

County governments
State governments
Federally recognized Native American tribal governments
Public and Indian housing authorities
City or township governments

Business

For-profit organizations other than small businesses
Small businesses

Miscellaneous

Other

Additional information

Higher Education Institutions - Includes all typesPublic/State Controlled Institutions of Higher EducationPrivate Institutions of Higher EducationNonprofits Other Than Institutions of Higher EducationNonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)For-Profit OrganizationsSmall BusinessesFor-Profit Organizations (Other than Small Businesses)Local GovernmentsState GovernmentsCounty GovernmentsCity or Township GovernmentsSpecial District GovernmentsIndian/Native American Tribal Governments (Federally Recognized)Indian/Native American Tribal Governments (Other than Federally Recognized)Federal GovernmentsEligible Agencies of the Federal GovernmentU.S. Territory or PossessionOtherIndependent School DistrictsPublic Housing Authorities/Indian Housing AuthoritiesNative American Tribal Organizations (other than Federally recognized tribal governments)Faith-based or Community-based OrganizationsRegional OrganizationsNon-domestic (non-U.S.) Entities (Foreign Organizations)Foreign OrganizationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grantor contact information

Description

Tiina K. Urv, Ph.D.

Email

urvtiin@mail.nih.gov

Documents

File name	Description	Last updated
PAR-25-438__Rare_Diseases_Clinical_Research_Consortia_RDCRC_for_the_Rare_Diseases_Clinical_Research_Network_RDCRN_U54_Clinical_Trial_Optional.html	PAR-25-438 Revised Full Announcement	Jun 6, 2025 04:23 PM UTC

Link to additional information

https://grants.nih.gov/grants/guide/notice-files/NOT-TR-25-008.html

Archived: February 7, 2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

Expected awards

$--

Award Minimum

$1,000,000

Award Maximum

Funding opportunity number:

PAR-25-438

Cost sharing or matching requirement:

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

June 5, 2025

Archive date:

February 7, 2026