Opportunity Listing - Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)

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Rare Diseases Clinical Research Consortia (RDCRC) for the Rare Diseases Clinical Research Network (RDCRN) (U54 Clinical Trial Optional)

Agency: National Institutes of Health

Assistance Listings: 93.350 -- National Center for Advancing Translational Sciences

93.866 -- Aging Research

93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders

93.865 -- Child Health and Human Development Extramural Research

93.837 -- Cardiovascular Diseases Research

93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research

93.847 -- Diabetes, Digestive, and Kidney Diseases Extramural Research

93.855 -- Allergy and Infectious Diseases Research

93.172 -- Human Genome Research

93.838 -- Lung Diseases Research

93.121 -- Oral Diseases and Disorders Research

93.839 -- Blood Diseases and Resources Research

93.233 -- National Center on Sleep Disorders Research

Last Updated: June 5, 2025

Description

The objective of this Notice of Funding Opportunity (NOFO) is to invite new and renewal applications for the Rare Diseases Clinical Research Consortia (RDCRC) that comprise the Rare Diseases Clinical Research Network (RDCRN). The RDCRCs are intended to advance and improve diagnosis, management, and treatment of numerous, rare diseases through highly collaborative, multi-site, patient-centric, translational, and clinical research. Special emphasis will be placed on the early and timely identification of individuals with rare diseases and clinical trial readiness.

Eligibility

Eligible applicants

Nonprofit

Other Native American tribal organizations
Nonprofits non-higher education with 501(c)(3)

Government

Public and Indian housing authorities
Federally recognized Native American tribal governments
State governments
City or township governments
County governments

Business

Small businesses
For-profit organizations other than small businesses

Education

Independent school districts
Public and state institutions of higher education
Private institutions of higher education

Miscellaneous

Other

Additional information

Higher Education Institutions - Includes all typesPublic/State Controlled Institutions of Higher EducationPrivate Institutions of Higher EducationNonprofits Other Than Institutions of Higher EducationNonprofits with 501(c)(3) IRS Status (Other than Institutions of Higher Education)Nonprofits without 501(c)(3) IRS Status (Other than Institutions of Higher Education)For-Profit OrganizationsSmall BusinessesFor-Profit Organizations (Other than Small Businesses)Local GovernmentsState GovernmentsCounty GovernmentsCity or Township GovernmentsSpecial District GovernmentsIndian/Native American Tribal Governments (Federally Recognized)Indian/Native American Tribal Governments (Other than Federally Recognized)Federal GovernmentsEligible Agencies of the Federal GovernmentU.S. Territory or PossessionOtherIndependent School DistrictsPublic Housing Authorities/Indian Housing AuthoritiesNative American Tribal Organizations (other than Federally recognized tribal governments)Faith-based or Community-based OrganizationsRegional OrganizationsNon-domestic (non-U.S.) Entities (Foreign Organizations)Foreign OrganizationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grantor contact information

Description

Tiina K. Urv, Ph.D.

Email

urvtiin@mail.nih.gov

Documents

File name	Description	Last updated
PAR-25-438__Rare_Diseases_Clinical_Research_Consortia_RDCRC_for_the_Rare_Diseases_Clinical_Research_Network_RDCRN_U54_Clinical_Trial_Optional.html	PAR-25-438 Revised Full Announcement	Jun 6, 2025 04:23 PM UTC

Link to additional information

https://grants.nih.gov/grants/guide/notice-files/NOT-TR-25-008.html

Closing: October 16, 2025

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

Expected awards

$--

Award Floor

$1,000,000

Award Ceiling

Funding opportunity number:

PAR-25-438

Cost sharing or matching requirement:

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

June 5, 2025

Archive date:

November 15, 2025