Isotopes are high-priority commodities of strategic importance for the Nation and are essential in medical diagnosis and treatment, discovery science, national security, industrial processes, advanced manufacturing, space exploration, communications, biology, archaeology, quantum information science, clean energy, environmental science, and other fields. Isotopes can directly enable emerging technologies and contribute to the economic, technical, and scientific strength of the United States. The DOE Office of Science Program for Isotope R&D and Production (also referred to as the DOE Isotope Program or DOE IP) routinely funds research and development (R&D) in isotope science to advance fundamental understanding and develop cutting edge and efficient technologies for enriching, producing, processing, recycling, and purifying radioactive and stable isotopes in short supply. This Notice of Funding Opportunity (NOFO) is narrowly focused on topics involving AI/ML, enhanced processing chemistry used in matter phase changes, and separation science. Applications incorporating effective ways to train the next generation of personnel with essential knowledge and skills related to the production, processing, and purification of radioactive and enriched stable isotopes are strongly encouraged.  

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