Opportunity Listing - BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)

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BRAIN Initiative: New Concepts and Early-Stage Research for Recording and Modulation in the Nervous System (R21) (Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders

93.173 -- Research Related to Deafness and Communication Disorders

93.279 -- Drug Use and Addiction Research Programs

93.286 -- Discovery and Applied Research for Technological Innovations to Improve Human Health

93.213 -- Research and Training in Complementary and Integrative Health

93.866 -- Aging Research

93.865 -- Child Health and Human Development Extramural Research

93.273 -- Alcohol Research Programs

93.867 -- Vision Research

93.242 -- Mental Health Research Grants

Last Updated: January 3, 2025

View version history on Grants.gov

Description

A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens...

or hundreds of neurons, out of a total number in the human brain estimated at 85 billion.Other BRAIN FOAs seek to develop novel technology (RFA-NS-17-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-17-004) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization.In addition to experimental approaches, the support provided under this FOA might enable calculations, simulations, computational models, or other mathematical techniques for demonstrating that the signal sources and/or measurement technologies are theoretically capable of meeting the demands of large-scale recording or manipulation of circuit activity in humans or in animal models. The support might also be used for building and testing phantoms, prototypes, in-vitro or other bench-top models in order to validate underlying theoretical assumptions in preparation for future FOAs aimed at testing in animal models.

Eligibility

Eligible applicants

Government

County governments
State governments
Public and Indian housing authorities
Special district governments
City or township governments
Federally recognized Native American tribal governments

Education

Public and state institutions of higher education
Private institutions of higher education
Independent school districts

Nonprofit

Other Native American tribal organizations
Nonprofits non-higher education with 501(c)(3)
Nonprofits non-higher education without 501(c)(3)

Business

Small businesses
For-profit organizations other than small businesses

Miscellaneous

Other

Additional information

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Grantor contact information

Description

NIH Grants Information grantsinfo@nih.gov

Email

See Section VII. Agency Contacts within the full opportunity announcement for all other inquires.

grantsinfo@nih.gov

Documents

File name	Description	Last updated
RFA-EY-25-001-Full-Announcement.html	RFA-EY-25-001 Full Announcement Text	Dec 9, 2024 06:26 PM UTC

Link to additional information

https://grants.nih.gov/grants/guide/rfa-files/RFA-EY-25-001.html

Closing: June 15, 2026

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$200,000

Program Funding

Expected awards

$--

Award Minimum

$200,000

Award Maximum

Funding opportunity number:

RFA-EY-25-001

Cost sharing or matching requirement:

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Income security and social services

Health

Category Explanation:

History

Version:

Posted date:

December 9, 2024

Archive date:

July 21, 2026