BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)
Agency: National Institutes of Health
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- 93.372 -- 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies
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Open opportunityLast Updated: Oct 21, 2026
View version history on Grants.gov
Description
This funding announcement, issued by the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, seeks transformative, cutting-edge, and innovative research that embraces new technologies, ideas, and approaches to understand brain circuit function and contributions to behavior. It is a component of the BRAIN Initiative Connectivity Across Scales (BRAIN CONNECTS) Program, which aims to lay the scientific foundation for the next generation of neural circuit-based approaches for preventing and treating devastating brain disorders.
This Notice of Funding Opportunity (NOFO) supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects using other species are also permitted, if their use is well justified and the goal is to test and validate approaches that can be generalized across species. Applications may address any aspect(s) of brain connectivity and associated data pipelines, including data collection, reconstruction, analysis, integration, dissemination, and interpretation, to enable faster, more precise, and more cost-effective generation and interpretation of brain-wide wiring diagrams. Funded projects will be integrated into the BRAIN CONNECTS Network consisting of projects funded under this and preceding BRAIN CONNECTS NOFOs, as a coordinated effort aimed at developing the capabilities to generate wiring diagrams that can span entire brains across multiple scales.
Eligibility
Eligible applicants
Education
- Public and state institutions of higher education
- Independent school districts
- Private institutions of higher education
Miscellaneous
- Other
Government
- Federally recognized Native American tribal governments
- Special district governments
- City or township governments
- County governments
- State governments
- Public and Indian housing authorities
Business
- For-profit organizations other than small businesses
- Small businesses
Nonprofit
- Nonprofits non-higher education with 501(c)(3)
- Other Native American tribal organizations
- Nonprofits non-higher education without 501(c)(3)
Additional information
Grantor contact information
Description
Scientific/Research Contact(s)
Documents
| File name | Description | Last updated |
|---|---|---|
| RFA-NS-27-015-Revised-Full-Announcement.html | RFA-NS-27-015-Revised-Full-Announcement.html | Oct 21, 2026 02:14 PM UTC |
Link to additional information
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Closing: October 4, 2027
Award
$10,000,000
Program Funding
--
Expected awards
$--
Award Minimum
$--
Award Maximum
Funding opportunity number:
RFA-NS-27-015
Cost sharing or matching requirement:
Funding instrument type:
Cooperative agreement
Opportunity Category:
Discretionary
Opportunity Category Explanation:
Category of Funding Activity:
Health
Category Explanation:
History
Version:
2
Posted date:
May 28, 2026
Archive date:
December 3, 2027
