Opportunity Listing - BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)

BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies (U01 Clinical Trial Not Allowed)

Agency: National Institutes of Health

Assistance Listings: 93.242 -- Mental Health Research Grants

93.173 -- Research Related to Deafness and Communication Disorders

93.279 -- Drug Use and Addiction Research Programs

93.865 -- Child Health and Human Development Extramural Research

93.866 -- Aging Research

93.286 -- Discovery and Applied Research for Technological Innovations to Improve Human Health

93.213 -- Research and Training in Complementary and Integrative Health

93.867 -- Vision Research

93.273 -- Alcohol Research Programs

93.372 -- 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies

93.853 -- Extramural Research Programs in the Neurosciences and Neurological Disorders

Last Updated: May 28, 2026

View version history on Grants.gov

Description

This funding announcement, issued by the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative, seeks transformative, cutting-edge, and innovative research that embraces new technologies, ideas, and approaches to understand brain circuit function and contributions to behavior. It is a component of the BRAIN Initiative Connectivity Across Scales (BRAIN CONNECTS) Program, which aims to lay the scientific foundation for the next generation of neural circuit-based approaches for preventing and treating devastating brain disorders.This Notice of Funding Opportunity (NOFO)...

supports Specialized Projects to develop current or emerging technologies to generate comprehensive atlases of brain connectivity, with an emphasis on human, non-human primate (NHP), and mouse. Projects using other species are also permitted, if their use is well justified and the goal is to test and validate approaches that can be generalized across species. Applications may address any aspect(s) of brain connectivity and associated data pipelines, including data collection, reconstruction, analysis, integration, dissemination, and interpretation, to enable faster, more precise, and more cost-effective generation and interpretation of brain-wide wiring diagrams. Funded projects will be integrated into the BRAIN CONNECTS Network consisting of projects funded under this and preceding BRAIN CONNECTS NOFOs, as a coordinated effort aimed at developing the capabilities to generate wiring diagrams that can span entire brains across multiple scales.

Eligibility

Eligible applicants

Government

County governments
Federally recognized Native American tribal governments
City or township governments
Special district governments
State governments
Public and Indian housing authorities

Education

Independent school districts
Private institutions of higher education
Public and state institutions of higher education

Nonprofit

Nonprofits non-higher education with 501(c)(3)
Other Native American tribal organizations
Nonprofits non-higher education without 501(c)(3)

Miscellaneous

Other

Business

For-profit organizations other than small businesses
Small businesses

Additional information

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility. Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Grantor contact information

Description

The Brain Research Through Advancing Innovative Neurotechnologies® (BRAIN) Initiative BRAIN-CONNECTS-Inquiries@nih.gov

Email

Scientific/Research Contact(s)

BRAIN-CONNECTS-Inquiries@nih.gov

Documents

File name	Description	Last updated
RFA-NS-27-015-Full-Announcement.html	RFA-NS-27-015-Full-Announcement.html	May 28, 2026 05:52 PM UTC

Link to additional information

Closing: October 4, 2027

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$10,000,000

Program Funding

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

RFA-NS-27-015

Cost sharing or matching requirement:

Funding instrument type:

Cooperative agreement

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Posted date:

May 28, 2026

Archive date:

December 3, 2027