Identify and Evaluate Potential Risk Factors for Amyotrophic Lateral Sclerosis (ALS)

research that will identify and evaluate risk factors contributing to ALS, with preferred focus in this Notice of Funding Opportunity on factors related to military service, contact sports, traumatic brain injury, neuroinflammation, and infectious agents. Research proposals on preferred topics can be funded under one of two funding options, Funding Option A or Funding Option B. Funding Option A is intended to support ALS risk factor research investigations that have an existing, well substantiated evidence base and would benefit from strengthened rigorous evaluation. Funding Option B is intended to support novel ALS risk factor research investigations that may or may not have an existing evidence base foundation base, may be supported by limited and insuffiicient preliminary research, and are exploratory and developmental in nature.