The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in conjunction with other NIH Institutes and Centers (ICs) as a part of the congressionally mandated NIH Helping to End Addiction Long Term (HEAL) initiative intends to publish a Notice of Funding Opportunity (NOFO) to leverage and accelerate the progress achieved in the Restoring Joint Health and Function to Reduce Pain (RE-JOIN) Consortium.

The NOFO aims to more fully refine and map the innervation of the different articular and peri-articular tissues that collectively form the joint (including bone, cartilage, synovium, joint capsule, ligament, tendon, fascia and muscle), by sensory neurons that mediate the sensation of pain.

The NOFO seeks to expand initial and ongoing efforts by:

• Enhancing clinical pain phenotyping with multimodal profiling of new and expanded patient samples across life span and disease conditions (i.e., other musculoskeletal and/or rheumatic conditions associated with joint pain beyond knee and temporomandibular joint (TMJ)).
• Expanding to new preclinical and New Approach Methodologies (NAMs) in modeling joint disease.
• Preclinical testing of novel joint-targeted candidates identified in RE-JOIN 1.0.
• Focusing on peri-articular tissues in joint pain, such as vasculature, synovium, adipose, myofascial tissue, etc.
• Prioritizing secondary analysis of datasets and/or validation of methods and approaches in human samples.
• Improve data integration by developing/enhancing joint atlases that will enable integration of imaging and molecular datasets.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful multidisciplinary collaborations and responsive projects. Investigators with expertise and insights in neurobiology, pain science, data science, orthopedics, rheumatic disease, etc. are encouraged to consider applying for this NOFO.

Education

• Private institutions of higher education
• Public and state institutions of higher education
• Independent school districts

Nonprofit

• Nonprofits non-higher education without 501(c)(3)
• Other Native American tribal organizations
• Nonprofits non-higher education with 501(c)(3)

Government

• State governments
• Special district governments
• Federally recognized Native American tribal governments
• City or township governments
• County governments
• Public and Indian housing authorities

Business

• For-profit organizations other than small businesses
• Small businesses

Miscellaneous

• Other