Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)

Agency: National Institutes of Health

93.859 -- Biomedical Research and Research Training
93.840 -- Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders
93.361 -- Nursing Research
93.173 -- Research Related to Deafness and Communication Disorders
93.213 -- Research and Training in Complementary and Integrative Health
93.866 -- Aging Research
93.279 -- Drug Use and Addiction Research Programs
93.172 -- Human Genome Research
93.233 -- National Center on Sleep Disorders Research
93.838 -- Lung Diseases Research
93.865 -- Child Health and Human Development Extramural Research
93.839 -- Blood Diseases and Resources Research
93.113 -- Environmental Health
93.350 -- National Center for Advancing Translational Sciences
93.837 -- Cardiovascular Diseases Research
93.867 -- Vision Research
93.121 -- Oral Diseases and Disorders Research
93.273 -- Alcohol Research Programs
93.846 -- Arthritis, Musculoskeletal and Skin Diseases Research
93.879 -- Medical Library Assistance

Forecasted opportunityLast Updated: May 27, 2026

Description

The National Institutes of Health (NIH), including the participating Institutes, Centers and Offices, intends to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I, and Fast-Track grant applications for the Small Business Transition Grant. Through this NOFO, NIH will support early-career scientists transitioning to entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R41/R42 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project.

Eligibility

Eligible applicants

Business

Small businesses

Additional information

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.

Grantor contact information

Description

NIH SEED (Small business Education and Entrepreneurial Development) Office of Extramural Research (OER) 301-827-8595

Email

SEEDinfo@nih.gov

Documents

No documents are currently available.

Link to additional information

Forecasted

Estimated Post Date:

November 5, 2026

Estimated Application Due Date:

January 5, 2027

Estimated Due Date Description:

Not available

Estimated Award Date:

June 1, 2027

Estimated Project Start Date:

July 1, 2027

Fiscal Year:

2027

Application process

This site is a work in progress. Go to www.grants.gov to apply, track application status, and subscribe to updates.

Award

$--

Program Funding

Expected awards

$--

Award Minimum

$--

Award Maximum

Funding opportunity number:

PAR-27-040

Cost sharing or matching requirement:

Funding instrument type:

Grant

Opportunity Category:

Discretionary

Opportunity Category Explanation:

Category of Funding Activity:

Health

Category Explanation:

History

Version:

Forecast posted date:

May 27, 2026

Archive date: